Does Lemon Tea Have Vitamin C

Joshua Desember 05, 2021

Does Lemon Tea Have Vitamin C

Kojic acid
KojicAcid.svg
Names
Preferred IUPAC name

5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
Other names

Kojic acid, 5-Hydroxy-2-(hydroxymethyl)-4-pyrone, 2-hydroxymethyl-5-hydroxy-γ-pyrone
Identifiers

CAS Number
  • 501-30-4 check Y

3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:43572 ☒ N
ChEMBL
  • ChEMBL287556 check Y
ChemSpider
  • 3708 check Y
DrugBank
  • DB01759 ☒ N
ECHA InfoCard 100.007.203 Edit this at Wikidata
EC Number
  • 207-922-4
KEGG
  • C14516 check Y

PubChem CID

  • 3840
RTECS number
  • UQ0875000
UNII
  • 6K23F1TT52 check Y

CompTox Dashboard (EPA)

  • DTXSID2040236 Edit this at Wikidata

InChI

  • InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2check Y

    Key: BEJNERDRQOWKJM-UHFFFAOYSA-Ncheck Y

  • InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2

SMILES

  • O=C1/C=C(\O/C=C1/O)CO
Properties

Chemical formula

 C6H6O4
Molar mass 142.11 g/mol
Appearance white
Melting point 152 to 155 °C (306 to 311 °F; 425 to 428 K)

Solubility in water

 Slight
Acidity (pK a) 9.40[1]
Hazards
R-phrases (outdated) R36/37/38
S-phrases (outdated) S22, S24/25

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ Nverify (what is check Y ☒ N  ?)
Infobox references

Chemical compound

Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji.[2] [3] [4] Kojic acid is a by-product in the fermentation process of malting rice, for use in the manufacturing of sake, the Japanese rice wine.[2] It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances.[5] It forms a bright red complex with ferric ions.[6]

Biosynthesis [edit]

13C-Labeling studies have revealed at least two pathways to kojic acid. In the usual route, dehydratase enzymes convert glucose to kojic acid. Pentoses are also viable precursors in which case dihydroxyacetone is invoked as an intermediate.[2]

Applications [edit]

Kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin. As an example of the latter, it is used to treat skin diseases like melasma.[7] Kojic acid also has antibacterial and antifungal properties.[ citation needed ] The cocrystals of kojic acid with quercetin were found to have two times better cytotoxic activity to human cervical cancer cells (HeLa) and human colon cancer cells (Caco-2) in comparison with quercetin itself.[8]

Other effects [edit]

Kojic acid has been shown to protect Chinese hamster ovary cells against ionizing radiation-induced damage. Dogs pretreated with kojic acid after whole-body exposure to a lethal dose of 3 Gy gamma radiation had a 51-day survival rate of 66.7% versus the dogs in the 3 Gy irradiation only group, which all died within 16 days of postirradiation.[9]

References [edit]

  1. ^ Bjerrum, J., et al. Stability Constants, Chemical Society, London, 1958.
  2. ^ a b c Bentley, R. (2006). "From miso, sake and shoyu to cosmetics: a century of science for kojic acid". Nat. Prod. Rep. 23 (6): 1046–1062. doi:10.1039/b603758p. PMID 17119644.
  3. ^ Yabuta T (1924). "The constitution of kojic acid, a gamma-pyrone derivative formed by Aspergillus oryzae from carbohydrates". Journal of the Chemical Society. 125: 575–587. doi:10.1039/ct9242500575.
  4. ^ Parvez, Shoukat; Kang, Moonkyu; Chung, Hwan-Suck; Cho, Chongwoon; Hong, Moo-Chang; Shin, Min-Kyu; Bae, Hyunsu (2006). "Survey and mechanism of skin depigmenting and lightening agents". Phytotherapy Research. 20 (11): 921–34. doi:10.1002/ptr.1954. PMID 16841367. S2CID 22156361.
  5. ^ Kojic acid and enzymatic browning Archived 2008-03-04 at the Wayback Machine
  6. ^ Nurchi, Valeria M.; Lachowicz, Joanna I.; Crisponi, Guido; Murgia, Sergio; Arca, Massimiliano; Pintus, Anna; Gans, Peter; Niclos-Gutierrez, Juan; Domínguez-Martín, Alicia; Castineiras, Alfonso; Remelli, Maurizio (2011-05-27). "Kojic acid derivatives as powerful chelators for iron(III) and aluminium(III)". Dalton Transactions. 40 (22): 5984–5998. doi:10.1039/C1DT00005E. ISSN 1477-9234. PMID 21552634.
  7. ^ Melasma Archived 2009-12-23 at the Wayback Machine, American Academy of Dermatology
  8. ^ Veverka, M., Dubaj, T., Gallovič, J., Jorík, V., Veverková, E., Danihelová, M., & Šimon, P. (2015). Cocrystals of quercetin: synthesis, characterization, and screening of biological activity. Monatshefte für Chemie-Chemical Monthly,146(1), 99-109 doi:10.1007/s00706-014-1314-6
  9. ^ Wang, Kai; Li, Peng-Fei; Han, Chun-Guang; Du, Li; Liu, Chao; Hu, Ming; Lian, Shi-Jie; Liu, Yong-Xue (2014). "Protective Effects of Kojic Acid on the Periphery Blood and Survival of Beagle Dogs after Exposure to a Lethal Dose of Gamma Radiation". Radiation Research. 182 (6): 666–673. Bibcode:2014RadR..182..666W. doi:10.1667/RR13823.1. PMID 25409121. S2CID 19066551.

External links [edit]

  • Safety MSDS data
  • Mohajer, Fatemeh; Mohammadi Ziarani, Ghodsi (2021). "An Overview of Quantitative and Qualitative Approaches on the Synthesis of Heterocyclic Kojic Acid Scaffolds through the Multi-Component Reactions". Heterocycles. Japan Institute of Heterocyclic Chemistry. 102 (2): 211. doi:10.3987/REV-20-936.

Does Lemon Tea Have Vitamin C

Source: https://en.wikipedia.org/wiki/Kojic_acid

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